Quillara Therapeutics Series A

Biotech pitch deck example, pipeline to runway

A life sciences investor decides on three things before they decide on the science: which asset is funded, what the data actually showed, and how long the money lasts. Quillara Therapeutics is invented, and its eleven slides answer those three in that order rather than opening on a market size.

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SERIES A

Fibrosis programme, 2027

Quillara Therapeutics

Three fibrosis assets, one mechanism, one readout in 30 months

Dr Ines Kovac, Dr Samuel Adeyemi

Chief Executive and Chief Scientist

Slide 1 · cover · Name the company, the programme and the one readout the round buys.

Why now

Scarring is where chronic kidney disease ends, and nothing approved treats the scar itself. Two things changed: the enzyme became druggable, and a urine marker replaced the biopsy.

The endpoint is scar

One in three people with type 2 diabetes develops kidney disease, and the kidney fails because it scars. Every approved medicine slows the cause, not the scar.

The target is druggable

The enzyme that cross links the scar sat outside reach until 2023, when three groups published oral inhibitors that hold their shape in the gut.

No biopsy needed

A urine collagen fragment now tracks scar burden closely enough to power a 180 patient study, which is what makes a 30 month trial affordable.

02

Slide 2 · intro · Why a fibrosis company can be funded now, stated from the biology rather than the market.

What Quillara has that most fibrosis work lacks

Every fibrosis company says it blocks scarring. The question a specialist asks is whether the molecule reaches the kidney, whether the effect can be measured without cutting, and whether a patient will take it for two years.

An oral molecule that reaches the kidney

QLR-201 concentrates about nine times higher in kidney tissue than in plasma in the rat, so the dose that works on the scar does not have to flood the rest of the body. That ratio is why a once daily tablet is possible at all, and it is the finding the whole programme rests on.

A marker that reads scar without a biopsy

Urinary collagen fragment PRO-C6 moved in step with measured scar in the 12 week model and fell 41 percent in the Phase 1 multiple dose cohort. It is the Phase 2 primary endpoint, so the study reads out from a urine sample rather than a needle.

A safety profile that survives two years of dosing

Forty eight healthy volunteers, no serious adverse events, one discontinuation at the top dose for a rash that cleared in four days. A chronic scarring disease needs years of tablets, so tolerability is not a footnote here.

03

Slide 3 · pillars · The three things Quillara owns, each tied to a piece of evidence rather than a claim.

The pipeline

One asset in each phase, all three from the same chemistry, only the lead is funded by this round.

QLR-201, Phase 2

Indication

Diabetic kidney disease, stage 3, where scarring is already measurable and no treatment targets it.

Next milestone

First patient dosed four months after close, topline at month 30. This round pays for all of it.

QLR-140, Phase 1

Indication

Liver fibrosis. Same enzyme, a second molecule tuned for liver tissue rather than kidney.

Next milestone

Multiple ascending dose completes month 9, funded by an existing grant of 2.1 million dollars.

QLR-072, preclinical

Indication

Lung fibrosis, inhaled. Six lead compounds, one chosen for toxicology in the second half of 2027.

Next milestone

Candidate selection only. No money in this round moves it, and it is not part of the ask.

Shared chemistry

What is common

One enzyme, one assay, one manufacturing route. A second asset costs chemistry time, not a new platform.

What is protected

Composition of matter granted in the United States and Europe, covering all three series to 2043.

04

Slide 4 · framework · The pipeline by phase, so an investor can see what the round funds and what it does not.

QLR-201 against standard of care

Same model, same 12 weeks

Measure

Current care

QLR-201

Difference

Fibrosis score improved

31%

54%

23 pts

Scar area at week 12

14.2%

7.8%

6.4 pts

Filtration rate lost

4.1 mL

1.9 mL

54% less

Protein in urine

18%

41%

23 pts

Collagen marker fall

9%

38%

29 pts

Doses a day

Two

One

Simpler

Standard of care arm, 40 animals, 12 week model
QLR-201 arm, 40 animals, same model and readers

05

Slide 5 · comparison · Standard of care against the lead compound in the same model, measure by measure.

PHASE 1

Forty eight volunteers, four arms

Measure
Placebo
50 mg
150 mg
300 mg
Participants
12
12
12
12
Any adverse event
4
5
5
7
Serious adverse events
0
0
0
0
Discontinued
0
0
0
1
Target engagement
None
38%
71%
82%
Collagen marker fall
2%
11%
29%
41%
Half life, hours
None
11.2
11.8
12.1
Single and multiple ascending dose, completed September 2026. 300 mg carries into Phase 2.

06

Slide 6 · metrics · The Phase 1 safety and exposure table, because the Phase 2 dose has to be defended.

IND to topline, 30 months

Five six month blocks. The trial and the manufacturing package run together, which is what keeps it to 30 months.

Task
Mo 1 to 6
Mo 7 to 12
Mo 13 to 18
Mo 19 to 24
Mo 25 to 30
IND filed
Regulatory
Filed in month two, 30 day review clock
Sites activated
Trial
24 sites across four countries
Enrolment, 180 patients
Trial
Ten patients a month once all sites are live
Dosing and follow up
Trial
Six months on drug per patient
CMC scale up
Manufacturing
Tablet scaled to 40 kilogram batches
Topline readout
Regulatory
Collagen marker at month 30, unblinded

07

Slide 7 · timeline · The 30 months the round buys, drawn as bars so the overlap between trial and manufacturing is visible.

Where the company stands

Everything raised so far has gone into the molecule. No debt, no convertible notes outstanding.

$6.2M

Raised to date

A seed in 2024 and a bridge in 2026, across three years and two institutional holders.

22

Months of runway

3.1 million dollars in the bank at the current burn of 140,000 dollars a month.

2

Patents granted

Composition of matter in the United States and Europe, filed 2024, granted 2026.

08

Slide 8 · metrics · Cash, runway and protection in three numbers, so the ask is read against what is already in the bank.

Who does the work

Eleven people today. Six of the eight hires in this round sit in the left column.

Inside the company

Dr Ines Kovac, chief executive. Ran the renal programme at a mid size pharmaceutical company for nine years, two assets into Phase 2.

Dr Samuel Adeyemi, chief scientist. Published the first oral inhibitor of this enzyme in 2023 and holds the original patent.

A clinical operations lead and two clinical research associates, hired in the first quarter after close.

A biostatistician and two medicinal chemists, hired by month nine, to hold the Phase 2 analysis and the QLR-072 selection.

Around the company

Three practising nephrologists on the steering committee, each running a site, none holding equity.

An independent data monitoring committee of four, contracted before first patient in, as the protocol requires.

A contract research organisation that has run eleven renal studies, chosen on site network rather than price.

A manufacturing partner already making the tablet at kilogram scale, with the 40 kilogram run quoted and slotted.

09

Slide 9 · content · Who runs the trial and who checks the science, listed as named roles rather than logos.

The ask

Sized to one readout, not to a runway target. Everything below happens before month 30.

$14M

Series A, opening January 2027, to a Phase 2 topline result

$8.4M

The Phase 2 trial

Sixty percent. 180 patients, 24 sites, 30 months from filing to topline, including the monitoring committee.

$3.5M

Manufacturing and supply

Twenty five percent. Scale the tablet to 40 kilogram batches and file the manufacturing package with the trial.

$2.1M

Team

Fifteen percent. Eight hires in total, four of them clinical, all in place by month nine so nothing waits on a vacancy.

10

Slide 10 · investment · The ask split three ways, each share tied to something in the timeline rather than a department.

Topline in month 30

The data room opens on request. The protocol, the Phase 1 report and the patent grants are already in it.

Email

ines@quillaratx.example

Phone

+61 8 7010 4422

Laboratory

Thebarton, South Australia

11

Slide 11 · closing · Close on the one date that matters and the two people who answer for it.

The structure

What each slide is doing, so you can reuse the order even with different content.

Slide 1cover
Name the company, the programme and the one readout the round buys.
Slide 2intro
Why a fibrosis company can be funded now, stated from the biology rather than the market.
Slide 3pillars
The three things Quillara owns, each tied to a piece of evidence rather than a claim.
Slide 4framework
The pipeline by phase, so an investor can see what the round funds and what it does not.
Slide 5comparison
Standard of care against the lead compound in the same model, measure by measure.
Slide 6metrics
The Phase 1 safety and exposure table, because the Phase 2 dose has to be defended.
Slide 7timeline
The 30 months the round buys, drawn as bars so the overlap between trial and manufacturing is visible.
Slide 8metrics
Cash, runway and protection in three numbers, so the ask is read against what is already in the bank.
Slide 9content
Who runs the trial and who checks the science, listed as named roles rather than logos.
Slide 10investment
The ask split three ways, each share tied to something in the timeline rather than a department.
Slide 11closing
Close on the one date that matters and the two people who answer for it.

Slide by slide

Slide one names the company and the readout the round buys. Slide two argues why now from the biology, with three supporting facts. Slide three is the three things the company owns, each tied to a piece of evidence. Slide four is the pipeline, one asset per phase plus the shared chemistry row. Slide five compares standard of care with the lead compound on six measures in the same model. Slide six is the Phase 1 safety and exposure table across placebo and three doses. Slide seven is the 30 month Gantt from IND filing to topline. Slide eight is cash, runway and patents in three numbers. Slide nine lists who does the work inside and around the company. Slide ten splits the 14 million three ways. Slide eleven closes on the readout date and the data room.

How to adapt this deck

A single asset company cuts slide four to one row and gives the space back to the data, which is the right trade when there is nothing else in the portfolio to fund. A platform company reverses the emphasis: the chemistry row becomes its own slide and the three assets become evidence that the platform repeats. A company raising against a clinical readout rather than towards one swaps the Gantt for the readout itself and moves the cash slide to second, because at that point runway is the question and the timeline is history.

What this audience asks for

The United States regulator sets out what an investigational new drug application has to contain before a first human dose, and its clinical research pages describe how the phases are meant to be sequenced. Those two documents are the reason a pipeline slide is organised by phase at all, and why a deck that blurs preclinical and Phase 1 is read as evasive. Accelerator guidance on deck design adds the other half: keep one idea per slide and let the numbers carry the argument, rather than writing the argument out and leaving the numbers in an appendix.

What makes this deck work

The pipeline says what is not funded

Slide four lists three assets by phase and then says out loud that the preclinical programme gets none of this money and is not part of the ask. Most pipeline slides imply the whole portfolio is being funded. Naming the one asset the round pays for is what makes the 14 million believable.

The model data is a subtraction, not a claim

Slide five puts standard of care beside the lead compound on six measures from the same 12 week model, with 40 animals in each arm named in the footer. Fibrosis score 31 percent against 54 is the headline, and the other five rows are there so the headline cannot be read alone.

The Gantt and the ask are the same 30 months

The bars on slide seven end at a topline readout in month 30, and the ask on slide ten is sized to that readout rather than to a runway target. Sixty percent of the money is the trial those bars describe, which is why the two slides cannot drift apart.

Questions people ask

What goes in a biotech pitch deck?

Why the biology is tractable now, what the company owns that others do not, the pipeline by phase, the data that supports the lead asset, the safety picture, the development timeline, cash and runway, the team and the ask. This example uses eleven slides and spends four of them on data.

How many slides should a biotech deck be?

Ten to twelve for a first meeting. This one is eleven. The appendix carries the protocol, the full toxicology package and the patent grants, because a specialist will ask for those and a generalist partner will not read them in the room.

Where does the pipeline slide go?

Early, usually third or fourth, and before any market sizing. An investor needs to know which asset they are being asked to fund before they can judge anything else. Putting it after the market slide makes the whole deck read as a platform pitch rather than an asset pitch.

Should preclinical data be in the main deck?

Yes, if the lead asset rests on it, and with the arm sizes and the model named. This example puts 40 animals per arm and a 12 week model in the footer of slide five. Data without a method line is treated as marketing by anybody who reads it properly.

How do you show runway without looking desperate?

State the cash, the burn and the months plainly on one slide, as this deck does with 3.1 million dollars at 140,000 a month. Investors work the number out anyway. A company that reports it first is describing a plan, and one that hides it is answering a question later.

Do I need a Gantt chart in a biotech deck?

Only if the overlap matters. Here the manufacturing package runs alongside the trial, and that overlap is what keeps the programme to 30 months, so the bars earn their slide. A list of five dates would say less. The Gantt in this builder holds up to 12 tasks and carries no dependency arrows.

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